When initiating invasive ventilation in a patient with acute respiratory distress syndrome (ARDS), which ventilator setting is most important to reduce the risk of ventilator-induced lung injury?
Positive end-expiratory pressure (PEEP) of 5 cmH2O
Tidal volume of 6 mL/kg of predicted body weight
FiO2 set to 100%
Respiratory rate of 18 breaths per minute