A 45-year-old patient presents to the emergency department with a history of diabetes mellitus and recent foot ulcer. The patient complains of increased pain, redness and swelling in the proximal left lower limb. Which of the following would be the BEST initial step in the management of suspected osteomyelitis?
Initiate NSAIDs for pain management.
Initiate empiric broad-spectrum antibiotics.
Order an MRI of the affected area.
Send blood cultures.